Methylene blue inhibits GABA A receptors by interaction with GABA binding site
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چکیده
منابع مشابه
Benzodiazepines affect channel opening of GABA A receptors induced by either agonist binding site.
Benzodiazepines are widely used as anxiolytics, sedatives, muscle relaxants, and anticonvulsants. They allosterically modulate GABA type A (GABA(A)) receptors by increasing the apparent affinity of the agonist GABA to elicit chloride currents. Such an increase in apparent affinity of channel gating could either be caused by an increase in affinity for GABA or by a facilitation of channel openin...
متن کاملGABA Receptors
Ian Martin is Professor of Pharmacology in the School of Life and Health Sciences at the University of Aston, Birmingham B4 7ET, UK. Susan Dunn is a Senior Lecturer in the Department of Pharmacology at the University of Bristol, University Walk, Bristol BS8 1TD, UK. They have common interests in GABAergic transmission in the central nervous system and their research is focused on the structure-...
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Depending on their subunit composition, GABA(A) receptors can be highly sensitive to Zn(2+). Although a pathological role for Zn(2+)-mediated inhibition of GABA(A) receptors has been postulated, no direct evidence exists that endogenous Zn(2+) can modulate GABAergic signaling in the brain. A possible explanation is that Zn(2+) is mainly localized to a subset of glutamatergic synapses. Hippocamp...
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GABA is the main inhibitory neurotransmitter in the mammalian CNS. GABA in the brain is commonly associated with a fast, point-to-point form of signalling called synaptic transmission (phasic inhibition), but there is growing evidence that GABA participates in another, slower and more diffuse form of signalling often referred to as tonic inhibition. Unresolved questions regarding tonic neuronal...
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The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (gamma-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABA(A) and GABA(C) receptors, and specific interactions between GABA and some of these residues have been determined. In the present paper, I show how...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2017
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2017.04.002